research
The Shendure Lab is part of the Howard Hughes Medical Institute, Seattle Hub for Synthetic Biology and the Department of Genome Sciences at the University of Washington (Seattle, WA). The mission of our lab is to develop and apply new technologies and methods at the intersection of genomics, molecular biology and developmental biology. Our research group pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays, saturation genome editing; combinatorial single cell molecular technologies; and genome editing based molecular recording technologies. Our ongoing work generally falls into the following areas, which are listed below as links to representative publications in each area.
Developing New Molecular Methods
Genomic Approaches to Developmental Biology
Massively Parallel Functional Genomics
Translating Genomics to the Clinic